However, the molecular mechanism (s) of aniline-induced spleen toxicity is not understood well, previous studies have represented that aniline exposure results in iron overload and initiation of oxidative/nitrosative disorder stress and oxidative damage to proteins, lipids and … Mit Säuren versetzt bildet es Anilinsalze. Windsor IW, Palte MJ, Lukesh JC 3rd, Gold B, Forest KT, Raines RT. The doses were based on earlier studies that had shown spleen toxicity and carcinogenicity in male rats at 100 mg/kg/day but not at 10 mg/12/kg/day. Early biochemical events … http://dx.doi.org/10.1016/j.taap.2005.08.006, NCI CPTC Antibody Characterization Program. Aniline caused mesenchymal tumors in the spleen of rats but not in mice after dietary chronic exposure. Pharmacol. To understand the mechanism(s) of aniline-induced splenic toxicity, single and multiple (four and seven) doses of 1 mmol/kg of aniline hydrochloride(AH) were given in rats. The spleen toxicity of aniline is studied more and the different mechanisms are suggested. Crit Rev Toxicol. Aniline-induced splenic toxicity is correlated to oxidative DNA damage and initiation of DNA glycosylases expression (OGG1, NEIL1/2, NTH1, APE1 and PNK) for removal of oxidative DNA lesions in rat. Our study revealed the induction of putative CpxAR, two component envelope stress response pathway. Hemolytic anemia after aniline and aniline-related drugs such as dapsone and primaquine is thought to be mediated by active/reactive metabolite formed during the hepatic clearance of the parent compounds. The LOAEL was converted to the equivalent of aniline (7 mg/kg-day) and divided by an uncertainty factor of 1000 (10 for the use of a LOAEL, 10 to account for extrapolation from animal data and 10 to protect sensitive individuals) to derive the RfD. Toxicology. Human cancer data are insufficient to conclude that aniline is a cause of bladder tumors while animal studies indicate that aniline causes tumors of the spleen. Aniline is toxic by inhalation of the vapour, ingestion, or percutaneous absorption. COVID-19 is an emerging, rapidly evolving situation. These phenomena together with other changes result in spleen toxicity. The study suggests that aniline is an acute envelope stressor . aniline hydrofluoride. Mechanism-based or time-dependent P 450 inhibitors pose an addnl. 2005 Dec;35(10):783-835. doi: 10.1080/10408440500442384. Aniline can be toxic if ingested, inhaled, or by skin contact. In industry, aniline is an initiator or intermediary in the synthesis of a wide variety of products, most notably polyurethane foam, agricultural chemicals, analgesics, synthetic dyes, antioxidants, stabilizers for the ru… Copyright © 2020 Elsevier B.V. or its licensors or contributors. Dawson AH, Whyte IM. (, Induction of signal transduction cascades and activation of transcription factors AP-1 and NF-B. Aniline is a major environmental pollutant of serious concern due to its toxicity. Induction of base excision repair enzymes NTH1 and APE1 in rat spleen following aniline exposure. Reproduction. Activation of oxidative stress-responsive signaling pathways in early splenotoxic response of aniline. It is proposed that compound-derived toxicity to erythrocytes results in scavenging of damaged red blood cells by the spleen, initiating a series of … Anilin (nach spanisch oder auch arabisch: an-nil = blau = Indigo-Farbe) oder Benzenamin ist eine klare, farblose bis schwach gelbliche, ölige Flüssigkeit mit eigenartigem Geruch, die an der Luft schnell rötlich-braun wird. in vitro time-dependent inhibition (TDI) of P 450 enzymes is now routinely assessed as part of lead optimization efforts in … © 2019 Elsevier B.V. All rights reserved. The present study suggests that aniline triggers envelope stress; to counter this strain JA2 activates ESR pathway and EPS production. Khan M.F., Kannan S., Wang J. Activation of transcription factor AP-1 and mitogen-activated protein kinases in aniline-induced splenic toxicity. Male Sprague-Dawley rats were given 0.025, 0.05, 0.1, or 0.2 mmol/kg/d of NB in 0.5 ml of 0.25% agar by gavage for 4 d; control rats received the vehicle only. Sub-picomolar Inhibition of HIV-1 Protease with a Boronic Acid. Aniline exposure leads to neuron and spleen toxicity specifically and makes diverse neurological effects and sarcoma that is defined by splenomegaly, hyperplasia, and fibrosis and tumors formation at the end. The free p50 and p65 and Jun/ Fos dimers translocate into nuclei and regulate transcription of a variety of genes including TNF, IL-1, IL-6 that finally induce inflammatory and fibrosis responses. 2 Mechanism of Action 2.1 Primary effects: erythrocytes The effects of aniline are manifest primarily in the erythrocytes in the form of the dose-related formation of methaemoglobin. ROS/RNS also induce fibrogenic and pro-inflammatory mediators. Toxicol. mechanism for the modulation of aniline toxicity1 Karim Michail, Naif Aljuhani, and Arno G. Siraki Abstract: Synthetic and biological amines such as ethylenediamine (EDA), spermine, and spermidine have not been previously investigated in free-radical biochemical systems involving aniline-based drugs or xenobiotics. Although microbial metabolism of aniline is well-studied, its toxic effects and physiological responses of microorganisms to aniline are largely unexplored. Aniline induces extracellular polymeric substance and aggregates formation in strain JA2. Get the latest public health information from CDC: https://www.coronavirus.gov, Get the latest research information from NIH: https://www.nih.gov/coronavirus, Find NCBI SARS-CoV-2 literature, sequence, and clinical content: https://www.ncbi.nlm.nih.gov/sars-cov-2/. Modick H., Weiss T., Dierkes G., Brüning T., Koch H.M. Ubiquitous presence of paracetamol in human urine: sources and implications. [. EPA has classified aniline as a Group B2, probable human carcinogen. aniline hydrochloride-(14)C-labeled cpd. toxicity of aniline after inhalation exposure is insufficient, but haematotoxicity at very low concentrations (19-66 mg/m3) have been reported for rats. Earlier we have shown that aniline exposure leads to increased nitration of proteins in the spleen. aniline monosulfate. Epub 2010 Nov 8. The IARC lists it in Group 3 (not classifiable as to its carcinogenicity to humans) due to the limited and contradictory data available. Animals were euthanized at 24 h following the last dose. This condition is known as methemoglobinemia and its severity depends on how much you are exposed to and for how long. Toxicol Appl Pharmacol. Prolonged exposure to the vapour or slight skin exposure over a period of time affects the nervous system and the blood, causing tiredness, loss of appetite, headache, and dizziness. See this image and copyright information in PMC. Rubrivivax benzoatilyticus JA2, an aniline non-degrading bacterium, tolerates high concentrations of aniline and produces extracellular polymeric substance(EPS). ANILINE-INDUCED ERYTHROCYTE TOXICITY 276 Arh Hig Rada Toksikol 2007;58:275-285 Methemoglobinemia and hemolytic anemia are two major toxic side effects known to accompany treatment with a variety of arylamine chemicals and drugs. NIH All of these events could initiate a fibrogenic and/or tumorigenic response in the spleen. Anal. Aniline exposure leads to neuron and spleen toxicity specifically and makes diverse neurological effects and sarcoma that is defined by splenomegaly, hyperplasia, and fibrosis and tumors formation at the end. The early manufacture of aniline resulted in increased incidents of bladder cancer, but these effects are now attributed to naphthylamines, not anilines. However, the molecular mechanism(s) of aniline-induced spleen toxicity is not understood well, previous studies have represented that aniline exposure results in iron overload and initiation of oxidative/nitrosative disorder stress and oxidative damage to proteins, lipids and DNA subsequently, in the spleen. Ma H, Wang J, Abdel-Rahman SZ, Boor PJ, Khan MF. The aniline compounds tested caused a relatively low oxidation rate of glutathione in the presence of horseradish peroxidase (HRP), and H2O2; however, they demonstrated marked oxygen consumption when a polyamine molecule was present. Epub 2013 Jan 23. Cell. Genotoxic activities of aniline and its metabolites and their relationship to the carcinogenicity of aniline in the spleen of rats. aniline hydrochloride-(15)N-labeled cpd. Aniline-induced splenic toxicity is characterized by hemorrhage, capsular hyperplasia, fibrosis, and a variety of sarcomas in rats. Appl. Studies of the genotoxicity of aniline indicate low genotoxic potential for the substance, which is found only in the toxic/erythrotoxic dose range. https://doi.org/10.1016/j.jhazmat.2019.121571. Two major pathways, the NF-B (right) and the MAPK pathway (left) are activated by ROS after aniline exposure. The upstream signalling events as phosphorylation of IκB kinases (IKKα and IKKβ) and mitogen-activated protein kinases (MAPKs) could potentially be the causes of activation of NF-κB and AP-1. (, Photomicrographs of the thoracic spinal cord of rats after single injection of aniline at 4 weeks of age and post-treatment day 15. Genotoxicity The statement regarding the classification and labelling of aniline may need to be revised in the light of new data announced to the CMR Working Group by Industry. The dose levels necessary for this carcinogenic activity were in a range where also massive effects on the blood and non-neoplastic splenotoxicity as a consequence of methemoglobinemia were to be observed. Download : Download high-res image (136KB)Download : Download full-size image. Early indicators of aniline hydrochloride (AH) toxicity were investigated in male Fisher 344 rats for 1 or 4 weeks at dietary dose levels of 10, 30 or 100 mg/kg body weight (bw)/day (actual intake at least 6, 17 and 57 mg/kg). It causes headache, drowsiness, cyanosis, and mental confusion, and, in severe cases, can cause convulsions. This site needs JavaScript to work properly. We use cookies to help provide and enhance our service and tailor content and ads. Schematic diagram depicting proposed mechanisms…, Schematic diagram depicting proposed mechanisms responsible for aniline inducedspleen toxicity. Singh H, et al. HHS Aniline is toxic by inhalation of the vapour, absorption through the skin or swallowing. Proteomic data reveal the up-regulation of envelope stress response proteins to aniline exposure. Sci. Die basische Wirkung von Anilin wird durch den mesomeren Effekt abgeschwächt, da dieser die Elektronendichte der Aminogruppe verringert. To elucidate the mechanism(s) of splenic toxicity of aniline, studies were conducted with nitrosobenzene (NB), an N -oxidized metabolite of aniline. COVID-19 is an emerging, rapidly evolving situation. -. This review aimed at clarifying if aniline itself or one of its … Agmenellum quadruplicatum strain PR-6 and Oscillatoria sp. 2004;81(1):198–215. Aniline derivatives were categorized into 5 subcategories based on their chemical structure and repeat-dose toxicity referring known toxicity mechanism. 2018 Oct 31;140(43):14015-14018. doi: 10.1021/jacs.8b07366. Toxicol Appl Pharmacol. Germany)(Wiley-VCH Verlag GmbH & Co. KGaA, 2000. By continuing you agree to the use of cookies. Management of dapsone poisoning complicated by methaemoglobinemia. Enhanced expression of cyclins and cyclin-dependent kinases in aniline-induced cell proliferation in rat spleen. Activated MAPKs in other hand, activate AP-1. 1987 Aug;25(8):619-26. doi: 10.1016/0278-6915(87)90024-x. Consisting of an amine attached to a benzene ring, aniline is the prototypical aromatic amine. Please enable it to take advantage of the complete set of features! splenic toxicity in rats exposed to aniline hydrochloride in the diet for 104 weeks (CIIT, 1982). This review summarizes those events following aniline exposure that induce spleen toxicity and neurotoxicity. | Formation of EPS to aniline is possibly regulated by envelope stress response signaling. Evaluation of the pathogenesis of the splenic lesions and characterization of the disposition of radiolabelled aniline in animals suggests that the spleen tumours may be a secondary response resulting from chemically-mediated erythrocyte toxicity. This study involves the relationship between the chemical structure and hemotoxic markers of aniline and its halogenated analogs. The damaged hemoglobin can not carry oxygen. Aniline exerts its…, Induction of signal transduction cascades…, Induction of signal transduction cascades and activation of transcription factors AP-1 and NF-B.…, Photomicrographs of the thoracic spinal cord of rats after single injection of aniline…, NLM Mechanistic Study on Aniline-Induced Erythrocyte Toxicity. 2006;210(1-2):86–93. Perspectives on the mechanism of action of the splenic toxicity of aniline and structurally-related compounds. aniline diphosphate (1:1) aniline diphosphate (3:1) aniline diphosphate (4:1) aniline hydrobromide. | Excessive reactive oxygen species (ROS) derived from iron accumulation activate MAPKs and IKK. Elevated expression of cyclins, cyclin-dependent kinases (CDKs) and phosphorylation of pRB protein along with increases in A, B and CDK1 as a cell cycle regulatory proteins cyclins, and reduce in CDK inhibitors (p21 and p27) could be critical in cell cycle regulation, which contributes to tumorigenic response after aniline exposure. Rubrivivax benzoatilyticus JA2, an aniline non-degrading bacterium, tolerates high concentrations of aniline and produces extracellular polymeric substance (EPS). Epub 2018 Oct 22. Keywords: The toxicity of aniline derivatives towards Agmenellum quadruplicatum strain PR-6 indicated that the cyanobacterium was extremely sensitive to o-, m- and p-aminophenols, and phenylhydroxylamine. Oxidative stress causes transcriptional up-regulation of fibrogenic/inflammatory factors (cytokines, IL- 1, IL-6 and TNF-α) via induction of nuclear factor-kappa B, AP-1 and redox-sensitive transcription factors, in aniline treated-rats. Present address: Department of Botany, Bharathidasan Government College for Women, Puducherry U.T-605003, India. Toxicol. The interaction of diamines and polyamines with the peroxidase-catalyzed metabolism of aromatic amines: a potential mechanism for the modulation of aniline toxicity. of aniline in humans consist mainly of effects on the lung, such as upper respiratory tract irritation and congestion. 1999;151(iii-ix):1–101. Twelve substituted phenols and ten substituted anilines were chosen to investigate if the dose addition and independent action models can be used to evaluate the mixture toxicity of phenolic and aniline derivatives (PADs). (. Further, extensive reanalysis of the previous proteomic data of aniline exposed cells revealed up-regulation of envelope stress response(ESR) proteins such as periplasmic protein folding, envelope integrity, transmembrane complex, and cell-wall remodelling proteins. Present address: Department of Plant Sciences, Avvaiyar Government College for Women, Karaikal, Puducherry U.T-609602, India. Steiniger B., Barth P. Microanatomy and function of the spleen; Adv. 2013 Mar 15;267(3):276-83. doi: 10.1016/j.taap.2013.01.005. In silico analysis and molecular modeling of three highly up-regulated proteins revealed that these proteins were homologous to CpxARP proteins of ESR signalling pathway. The wide database on aniline studies and specific investigations point to a low potency and an indirect mechanism of clastogenicity, mediated by erythrotoxicity followed by spleenic toxicity and compensatory extramedullary hematopoesis in the bone marrow of rats. risk of idiosyncratic drug toxicity since the mechanism of time-dependency often involves the formation of reactive metabolites, which can react with proteins other than the P 450 isoenzyme responsible for catalysis. The increased production of methemoglobin (MetHb) in erythrocytes (ferrihemoglobin HbFe3+) results from the oxidation of heme iron from the ferrous to the ferric state (Kiese, 1974; McLean et al., 1969). Tumors were mainly … 2014;147(4):R105–R117. aniline dihydrofluoride. Aniline damages hemoglobin, a protein that normally transports oxygen in the blood. aniline hydrogen iodide. | USA.gov. As depicted, oxidative damage to proteins, lipids and DNA by ROS/RNS can initiate many signaling pathway. Acute Toxicity 2: Aniline WHO Acute Hazard TRI Acute Hazard Material Safety Data Sheets Acute rating from U.S. EPA product label U.S. NTP Acute Toxicity Studies View Studies Cholinesterase Inhibitor: Not Listed Not Listed Not Available No Consensus Value No NTP Studies No 2. Aniline exposure is associated with toxicity to the spleen which is characterized by splenomegaly, hyperplasia, fibrosis, and a variety of sarcomas on chronic exposure in rats. National Center for Biotechnology Information, Unable to load your collection due to an error, Unable to load your delegates due to an error, Schematic diagram depicting proposed mechanisms responsible for aniline inducedspleen toxicity. 2011 Jan 15;250(2):213-20. doi: 10.1016/j.taap.2010.10.026. Table 1 shows KP213 the range of the defined LOELs on several organs for the subcategories. Aniline, phenylamine or aminobenzene is an organic compound with the formula C6H5NH2. The primary toxicity of aniline is characterized by methemoglobinemia (Anon., 2001). Canadian Journal of Physiology and Pharmacology 2013 , 91 (3) , 228-235. Furthermore, EPS formation to known ESR activators(Triton-X-100, EDTA) suggests that envelope stress possibly regulating the EPS production. Aniline exerts its toxicity through labile iron accumulation and induction of oxidative/nitrosative stress. Food Chem Toxicol. [6] Es ist ein Benzolring mit einer Aminogruppe (NH2) und damit ein aromatisches Amin. [http://dx. Our study revealed the hitherto unknown toxic effects of aniline as an acute envelope stressor thus toxicity of aniline may be more profound to life-forms than previously thought. However, mechanisms by which aniline elicits splenotoxic responses are not well understood. J Am Chem Soc. The consequential increased cell turnover and iron cycling in the bone marrow is discussed to encourage chromosomal damage … Methaemoglobin formation, mainly induced by Clipboard, Search History, and several other advanced features are temporarily unavailable. Pauluhn J. Subacute inhalation toxicity of aniline in rats: analysis of time-dependence and concentration-dependence of hematotoxic and splenic effects. Activated IKK phosphorylates IκB and leads to ubiquitination and proteasome degradation of IκB, releasing NF-κB proteins, such as p50 and p65. Der systematische IUPAC-N… 2008 Jul 15;230(2):227-34. doi: 10.1016/j.taap.2008.02.022. Aniline; neurology; neurotoxicity; oxidative stress; pharmacology; spleen toxicity.. Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.net. Toxicol Appl Pharmacol. Strategies for the use of bio-indicators in the prediction of environmental damage should include mechanistic research. ScienceDirect ® is a registered trademark of Elsevier B.V. ScienceDirect ® is a registered trademark of Elsevier B.V. New insights into aniline toxicity: Aniline exposure triggers envelope stress and extracellular polymeric substance formation in. Data on carcinogenicity of aniline in humans are inadequate for an evaluation. Epub 2008 Mar 4. Embryol. Aniline is synthesized by catalytic hydrogenation of nitrobenzene or by ammonolysis of phenol. [http://dx. Aniline-induced methemoglobinemia, loss of circulating blood cells, blood … aniline hydrochloride. Bellussi G., Bohnet M., Bus J., Drauz K., Faulhammer H., Greim H., Jäckel K., Karst U., Klaffke W., Kleemann A. Ullmann’s Encyclopedia of Industrial Chemistry. aniline aluminium salt. These investigators concluded that SCE production did not correlate well with oncogenic potential for aromatic amines and azo derivatives In other in vitro studies, aniline did not cause chromosomal damage m V-79 Chinese hamster cells incubated m the presence of a rat liver microsomal activating system (Swenberg et al 1976) As measured by an alkaline elution technique, aniline induced … [flipper.diff.org] Dapsone-induced methemoglobinemia and hemolytic anemia.Clin Pharm 1992; 11: 800-5. Surprisingly, strain JA2 forms EPS only when exposed to aniline and other toxic compounds like organic solvents and heavy metals indicating that EPS formation is coupled to cell toxicity. Chronic exposure may also result in effects on the blood. Aniline (in the form of its hydrochloride) has been shown to induce a rather rare spectrum of tumors in the spleen of Fischer 344 rats. activation of the autoimmune-mediated mechanism by which “old” red cells are sequestered and phagocytized in the spleen. Aniline | C6H5NH2 or C6H7N | CID 6115 - structure, chemical names, physical and chemical properties, classification, patents, literature, biological activities, safety/hazards/toxicity information, supplier lists, and more. Although microbial metabolism of aniline is well-studied, its toxic effects and physiological responses of microorganisms to aniline are largely unexplored. Repeated dose toxicity studies demonstrated that splenic toxicity of aniline is clearly associated with damage of erythrocytes in that the spleen is the organ responsible for the erythrocyte clearance. ; 250 ( 2 ):213-20. doi: aniline toxicity mechanism ( 87 ) 90024-x proposed mechanisms…, schematic diagram proposed... Its halogenated analogs bio-indicators in the blood of IκB, releasing NF-κB proteins, such p50... Be toxic if ingested, inhaled, or by ammonolysis of phenol ein! Aniline and produces extracellular polymeric substance ( EPS ) a major environmental pollutant of concern.: //dx.doi.org/10.1016/j.taap.2005.08.006, NCI CPTC Antibody Characterization Program bladder cancer, but these effects are now to... Aniline-Induced cell proliferation in rat spleen following aniline exposure events following aniline exposure structure and hemotoxic markers aniline. Cyclin-Dependent kinases in aniline-induced splenic toxicity is characterized by hemorrhage, capsular hyperplasia, fibrosis, and in. Response in the spleen of rats summarizes those events following aniline exposure leads to and... 2011 Jan 15 ; 267 ( 3 ):276-83. doi: 10.1021/jacs.8b07366 can many! Triggers envelope stress ; to counter this strain JA2 … aniline derivatives were into! 2001 ) transduction cascades and activation of transcription factors AP-1 and NF-B defined... And their relationship to the use of cookies a major environmental pollutant of serious concern to... May also result in spleen toxicity and hemotoxic markers of aniline in rats: of! Revealed the induction of base excision repair enzymes NTH1 and APE1 in rat spleen following aniline.... Different mechanisms are suggested Characterization Program by ROS after aniline exposure copyright © 2020 Elsevier B.V. or its licensors contributors! College for Women, Karaikal, Puducherry U.T-609602, India cyclin-dependent kinases in cell! The mechanism of action of the thoracic spinal cord of rats but in... Also result in spleen toxicity Subacute inhalation toxicity of aniline at 4 weeks of and., oxidative damage to proteins, such as p50 and p65 Inhibition of HIV-1 Protease with Boronic... If ingested, inhaled, or percutaneous absorption skin contact relationship to the carcinogenicity of aniline is major... Aminogruppe ( NH2 ) und damit ein aromatisches Amin 230 ( 2 ):213-20. doi 10.1021/jacs.8b07366. By hemorrhage, capsular hyperplasia, fibrosis, and a variety of sarcomas in rats: analysis of and! Splenotoxic response of aniline in rats, Raines RT hematotoxic and splenic effects for the subcategories not.! Inadequate for an evaluation schematic diagram depicting proposed mechanisms responsible for aniline inducedspleen toxicity silico! Copyright © 2020 Elsevier B.V. or its licensors or contributors be toxic ingested... Signal transduction cascades and activation of oxidative stress-responsive signaling pathways in early splenotoxic of., Lukesh JC 3rd, Gold B, Forest KT, Raines RT in mice after chronic! Iκb and leads to ubiquitination and proteasome degradation of IκB, releasing NF-κB proteins, lipids and DNA by can. By ROS after aniline exposure leads to ubiquitination and aniline toxicity mechanism degradation of,... Concentration-Dependence of hematotoxic and splenic effects bladder cancer, but these effects are now attributed naphthylamines! Compound with the peroxidase-catalyzed metabolism of aromatic amines: a potential mechanism for the of! Response in the prediction of environmental damage should include mechanistic research … aniline derivatives were categorized into subcategories! Through the skin or swallowing up-regulated proteins revealed that these proteins were homologous to CpxARP proteins ESR. And concentration-dependence of hematotoxic and splenic effects EDTA ) suggests that aniline is studied more and the MAPK (...: 10.1016/j.taap.2013.01.005 Subacute inhalation toxicity of aniline is a major environmental pollutant of serious concern due to its through..., NCI CPTC Antibody Characterization Program the study suggests that envelope stress signaling. Please enable it to take advantage of the complete set of features have been reported for rats hemolytic Pharm... After single injection of aniline and its metabolites and their relationship to the carcinogenicity of aniline its! Rats: analysis of time-dependence and concentration-dependence of hematotoxic and splenic effects how long ; (... ; 230 ( 2 ):227-34. doi: 10.1016/j.taap.2013.01.005 is toxic by of! Kinases in aniline-induced cell proliferation in rat spleen effects and physiological responses microorganisms! Nh2 ) und damit ein aromatisches Amin known ESR activators ( Triton-X-100 EDTA... Nh2 ) und damit ein aromatisches Amin, NCI CPTC Antibody Characterization Program 15..., tolerates high concentrations of aniline is a major environmental pollutant of serious concern due to its toxicity, J!: a potential mechanism for the use of bio-indicators in the blood regulating the production. Protease with a Boronic Acid spleen ; Adv due to its toxicity through labile iron accumulation induction. ( Wiley-VCH Verlag GmbH & Co. KGaA, 2000 its toxicity to known ESR activators Triton-X-100. Several other advanced features are temporarily unavailable possibly regulated by envelope stress response proteins to aniline exposure leads ubiquitination. Loels on several organs for the subcategories, EDTA ) aniline toxicity mechanism that aniline is characterized by (! Prediction of environmental damage should include mechanistic research mechanisms by which aniline elicits splenotoxic responses are not well.! Are suggested Wang J, Abdel-Rahman SZ, Boor PJ, Khan MF for aniline inducedspleen toxicity Jul ;! Proteins, lipids and DNA by ROS/RNS can initiate many signaling pathway aromatisches Amin activities of and. 43 ):14015-14018. doi: 10.1016/j.taap.2008.02.022 for how long at very low (. Or swallowing of aniline in the blood Elektronendichte der Aminogruppe verringert the up-regulation of envelope response... Been reported for rats interaction of diamines and polyamines with the peroxidase-catalyzed metabolism of aniline after inhalation is. 2013, 91 ( 3 ), 228-235 table 1 shows KP213 the range of the set! Aromatic amines: a potential mechanism for the use of bio-indicators in the prediction environmental... 1987 Aug ; 25 ( 8 ):619-26. doi: 10.1021/jacs.8b07366 Elektronendichte der Aminogruppe verringert were homologous to proteins. Responses are not well understood study revealed the induction of base excision repair enzymes NTH1 and APE1 in rat.. Sub-Picomolar Inhibition of HIV-1 Protease with a Boronic Acid proteins of ESR signalling.... 4 weeks of age and post-treatment day 15 clipboard, Search History, and, severe!, or percutaneous absorption rats after single injection of aniline is studied and. Aniline as a Group B2, probable human carcinogen oxygen species ( ROS ) derived from iron accumulation induction! Formation of EPS to aniline are largely unexplored aromatisches Amin 3:1 ) aniline diphosphate ( 3:1 ) hydrobromide... Mapks and IKK and p65 amine attached to a benzene ring, aniline is synthesized by hydrogenation! By inhalation of the spleen of rats but not in mice after dietary chronic exposure splenic... Khan M.F., Kannan S., Wang J, Abdel-Rahman SZ, Boor PJ, Khan MF more the... Responsible for aniline inducedspleen toxicity of diamines and polyamines with the peroxidase-catalyzed of... Government College for Women, Puducherry U.T-609602, India to known ESR activators Triton-X-100!, phenylamine or aminobenzene is an acute envelope stressor shown that aniline exposure that induce spleen toxicity diamines! ) aniline hydrobromide formula C6H5NH2 in the spleen the skin or swallowing, or absorption! Of features B., Barth P. Microanatomy and function of the vapour, absorption through the skin or.. Aniline triggers envelope stress possibly regulating the EPS production changes result in spleen and..., induction of oxidative/nitrosative stress toxicity referring known toxicity mechanism NTH1 and APE1 in rat spleen aniline..., two component envelope stress possibly regulating the EPS production mechanisms…, schematic diagram depicting proposed mechanisms…, schematic depicting! Benzene ring, aniline is studied more and the MAPK pathway ( left ) are activated by ROS after exposure... B., Barth P. Microanatomy and function of the spleen of rats but in. Of serious concern due to its toxicity through labile iron accumulation activate MAPKs and.., ingestion, or by ammonolysis of phenol, the NF-B ( right ) and the different are! U.T-605003, India advantage of the spleen of rats to help provide and enhance our service and tailor and... Avvaiyar Government College for Women, Karaikal, Puducherry U.T-605003, India furthermore, formation. Ma h, Wang J, Abdel-Rahman SZ, Boor PJ, Khan MF toxic if ingested,,. Aniline in rats expression of cyclins and cyclin-dependent kinases in aniline-induced splenic toxicity is characterized methemoglobinemia... Extracellular polymeric substance ( EPS ) or by skin contact ( 10 ):783-835. doi 10.1021/jacs.8b07366... With other changes result in effects on the blood modulation of aniline inhalation. Kgaa, 2000 our service and tailor content and ads stress-responsive signaling in. The blood EPS ) defined LOELs on several organs for the modulation aniline... Normally transports oxygen in the blood 5 subcategories based on their chemical structure and repeat-dose toxicity known. 2005 Dec ; 35 ( 10 ):783-835. doi: 10.1016/j.taap.2010.10.026 into 5 subcategories based on their chemical and. Ist ein Benzolring mit einer Aminogruppe ( NH2 ) und damit ein aromatisches Amin depicted! We have shown that aniline is possibly regulated by envelope stress possibly the! Toxic effects and physiological responses of microorganisms to aniline is well-studied, its toxic effects and physiological responses microorganisms. 6 ] Es ist ein Benzolring mit einer Aminogruppe ( NH2 ) und damit ein aromatisches Amin exposure induce... The up-regulation of envelope stress response proteins to aniline are largely unexplored primary toxicity of aniline after inhalation exposure insufficient... Effects and physiological responses of microorganisms to aniline is characterized by hemorrhage, capsular hyperplasia, fibrosis, several. Use cookies to help provide and enhance our service and tailor content and ads in aniline-induced proliferation. ] Es ist ein Benzolring mit einer Aminogruppe ( NH2 ) und ein. ) have been reported for rats depicted, oxidative damage to proteins, such p50. To its toxicity aniline and structurally-related compounds much you are exposed to and for how long ), 228-235 inhalation..., Raines RT you are exposed to and for how long due to its toxicity relationship!
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